Pengaruh Waktu Kneading Terhadap Efektifitas Enkapsulasi Molekul Minyak Kemenyan pada β-Siklodekstrin (β-CD)

Fauzan Setiawan, Sri Benti Etika Hesty Parbuntari

doi:10.33559/mi.v13i2.1221

Pengaruh Waktu Kneading Terhadap Efektifitas Enkapsulasi Molekul Minyak Kemenyan pada β-Siklodekstrin (β-CD)

Fauzan Setiawan, Sri Benti Etika Hesty Parbuntari

Sari

Frankincense essential oil (Boswellia sp.) is useful as aromatherapy, cosmetic ingredients,
antibacterial, anti-inflammatory and an anticancer, but essential oils are generally
unstable, susceptible to high temperatures, and easily oxidized. Encapsulation provides a
solution to the problem. β-cyclodextrin is a good coating for the encapsulation of essential
oils. Research has been conducted to determine the complex stability of inclusions with a
variety of kneading times. FT-IR analysis showed that there was a shift in the wavelength
between the parent molecule of β-cyclodextrin and the inclusion complex, namely the
increase of the hydroxyl group (-OH) in the inclusion complex so that the widening of the
absorbance band occurred. The melting point of the inclusion complex is almost close to
the pure melting point of β-cyclodextrin (>290ºC), the melting point of the inclusion
complex with variations in kneading time 15 minutes, 30 minutes, and 45 minutes
respectively 290ºC, 286ºC, and 278ºC. This high melting point shows inclusion complexes
that are stable and not easily damaged.
Keywords: encapsulation, frankincense, β-cyclodextrin, kneading, stability.

Teks Lengkap:

PDF

Referensi

Ahmed SM, Naggi A, Guerrini M, Focher B. (1991). Inclusion complexes of bioprimine

with β Cyclodextrin in solution and in solid state. Int. J. Pharm, 77, 247–254.

Akl, M.R., and P.W. Sylvester. (2013). Anticancer Activity of Boswellia (Frankincense)

Essential Oil. Essential Oils III and Phytopharmacology. RPMP Vol. 38.

Asbahani, A.El., Miladi, K., Badri, W., Sala, M., Addi, E. H.Aït., Casabianca, H.,.

Mousadik, A., El Hartmann., D. Jilale., A. Renaud., F. N.R. Elaissari, A. (2015).

Essential Oils: From Extraction to Encapsulation. International Journal of

Pharmaceutics. Vol. 483, Hal. 220-243.

Calderini, a. & Pessine, F. B. T. (2008).Synthesis and characterization of inclusion

complex of the vasodilator drug minoxidil with β-cyclodextrin. J. Incl. Phenom.

Macrocycl. Chem. 60, 369–377.

Duchѐne, Dominique. (2011). Cyclodextrins and Their Inclusion Complexes dalam

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine: Current and Future

Industrial Applications, First Edition. John Wiley & Sons, Inc..

Hamidi, H.; Abderrahim, R.; Meganem, F. (2010) Spectroscopic studies of inclusion

complex of β-cyclodextrin and benzidine diammonium dipicrate. Spectrochim. Acta

A, 75, 32–36.

Lee, C.W., S.J. Kim., Y.S. Youn., E. Widjojokusumo., Y.H. Lee., J. Kim., Y.W. Lee., and

R.R. Tjandrawinata. (2010). Preparation of Bitter Taste Masked Cetirizine

Dihydrochloride / β- Cyclodextrin Inclusion Complex by Supercritical Antisolvent

(SAS) Process. Journal of Supercritical Fluids. Vol. 55. Hal. 348–357. ISBN : 0896-

Marques, Cabral. Helena, M. (2010). A review on cyclodextrin encapsulation of essential

oils and volatiles. Flavour Fragr. J. 2010, 25, 313–326.

Mazzobre, M.F., B.E. Elizalde, C. dos Santos, P.A. Ponce Cevallos and M.P. Buera.

(2010). Nanoencapsulation of Food Ingredients in Cyclodextrins: Effect of Water

Interactions and Ligand Structure. Functional Food Product Development.

Blackwell Publishing Ltd. ISBN: 978-1-405-17876-1.

Nugraha, N. (2008). Analisis Faktor-Faktor Yang Mempengaruhi Harga Komoditas

Minyak Nilam Di Jawa Barat (Tesis). Depok : Fakultas Teknik Universitas

Indonesia.

Roik, N. & Belyakova, L. (2011). IR Spectroscopy, X-ray diffraction and thermal analysis

studies of solid ‘β-cyclodextrin-para-aminobenzoic acid’ inclusion complex. Phys.

Chem. Solid State 1, 168–173.

Rowe, C.R., Paul J Sheskey., and Mariam E Quinn. (2009). Handbook of Pharmaceutical

Excipients Sixth Edition. America : Pharmaceutical Press and American Pharmacists

Association.

Sagiri, Sai Sateesh., Arfat Anis., and Kunal Pal. (2016). Review on Encapsulation of

Vegetable Oils: Strategies, Preparation Methods, and Applications. Polymer -

Plastics Technology and Engineering. Vol. 55, No. 3, Hal. 291–311.

Santos EH., Kamimura JA., Hill LE., Gomes CL., (2015). Characterization of carvacrol

beta-cyclodextrin inclusion complexes as delivery systems for antibacterial and

antioxidant applications. LWT - Food Sci. Technol. 60 : 583–592.

Seo, Eun Ju., Min, Sang Gi., Choi, Mi Jun. (2010). Release Characteristics of Freeze-

Dried Eugenol Encapsulated with β-cyclodextrin by Molecular Inclusion Method.

Journal of Microencapsulation. Vol.27 (6): 496–505.

Singh, Ramnik., Nitin Bharti., Jyotsana Madan., S. N. Hiremath. (2010). Characterization

of Cyclodextrin Inclusion Complexes-A Review. Journal of Pharmaceutical Science

and Technology. Vol. 2, Issue (3), Hal. 171-183.

Supriyadi dan A. Sakha Rujita. (2013). Karakteristik Mikrokapsul Minyak Atsiri Lengkuas

dengan Maltodekstrin sebagai Enkapsulan. Jurnal Teknologi dan Industri Pangan.

Vol. 24 No. 2 ISSN: 1979-7788.

Szejtli, J. (1998). Introduction and General Overview of Cyclodextrin Chemistry. Chemical

Reviews. Vol. 98, No. 5.

Tang, B.; Chen, Z.-Z.; Zhang, N.; Zhang J.; Wang, Y. (2006) Synthesis and

characterization of a novel cross-linking complex of β-cyclodextrin-o-vanilin

furfaralhydrazone and highly selective spectrofluorimetric determination of trace

gallium. Talanta, 68, 575–580.

Xu, J., Zhang, Y., Li, X. & Zheng, Y. (2017). Inclusion complex of nateglinide with

sulfobutyl ether β-cyclodextrin: Preparation, characterization and water solubility. J.

Mol. Struct. 1141, 328–334

Zhu, Xiashi. Sun, Jing., Wu, Jun. (2007). Study on The Inclusion Interactions of Β-

Cyclodextrin and Its Derivative With Dyes by Spectrofluorimetry and Its Analytical

Application. Talanta. Vol. 72. Hal. 237–242

Zuidam, N and Heinrich, E. (2010). Encapsulation of Aroma dalam Encapsulation

Technologies for Active Food Ingredients and Food Processing. Unilever Research

and Development: The Netherlands

DOI: https://doi.org/10.33559/mi.v13i2.1221

Article Metrics

Sari view : 218 times
PDF - 705 times

Refbacks

Saat ini tidak ada refbacks.

##submission.copyrightStatement##

INDEXED BY :

Lembaga Penelitian & Pengabdian Masyarakat (LPPM). Universitas Muhammadiyah Sumatera Barat
Jl. Pasir Kandang No.4, Pasie Nan Tigo, Kec. Koto Tangah, Kota Padang, Sumatera Barat 25586.
Email : lppmumsb@gmail.com

Kunjungan Sampai Saat ini

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.