SINTESIS DAN UJI ANTIOKSIDAN SENYAWA (E)-1-(2-KLOROFENIL)-3-P-TOLILPROP-2-EN-1-ON

Eti Meirina Brahmana, Rena Lestari

Sari


Halogen substituted analog compound chalcone(E)-1-(2-chlorophenyl)-3-ptolylprop-
2-en-1-on was synthesized from 4-metylbenzaldehyde as aldehydes with 2-
chloroacetophenone, as ketones by using aldol condensation reaction. The compound
resulted rendement with value of 60,08% and characterized by using UV, IR, MS, and
1HNMR. Test of antioxidant activity using DPPH method showed that those compounds
have low potency as antioxidant agent LC50 with value 620,4506ppm.
Keywords: Antioxidant, DPPH, Chalcone, dan Synthesis


Teks Lengkap:

PDF

Referensi


Barhe, T.A dan Tchouya, G.R. 2014. Comparative Study of the Anti-oxidant Activity of the

Total Polyphenols Extracted from Hibiscus Sabdariffa L., Glycine max L Merr.,

Yellow Tea and Red Wine through Reaction with DPPH Free Radical. Arabian

Journal of Chemistry. 9:1-8.

Brahmana, E.M. 2015. Sintesis dan uji antibakteri senyawa (E)-1-(2-klorofenil)-3-ptolilprop-

-en-1-on. Jurnal Ilmiah Edu Research 4(2):103-108.

Choudhary, A.N., & Juyal, V. 2011. Synthesis of chalcone and their derivates as

antimicrobial agents. International journal of pharmacy and pharmaceutical

Sciences, 3(3): 125-128.

Jayapal, M.R., Prasad, K.S., & Sreedhar, N.Y. 2010. Synthesis and Characterization of 2,6-

Dihydroxy Substituted Chalcones Using PEG-400 as a Recyclable Solvent. Journal

of Pharmaceutical Science and Research. 2(8): 450-458.

Kakati, D., & Sarma ,J.C. 2011. Microwave Assisted Solvent Free Synthesis of 1,3-

Diphenylpropenones. Chemistry Central Journal. 5(8): 1-5.

Tiwari, B., Pratapwar, A.S., Tapas, A.R., Butle, S.R., & Vatkar, B.S. 2010. Synthesis and

Antimicrobial Activity of Some Chalcone Derivatives. International Journal of

ChemTech Research. 1(2): 499-503.

Vaismaa, M. 2009, Development of benign synthesis of some terminal a-hydroxy ketones

and aldehiydes. Disertasi: Faculty of Science University of Oulu.

Varma, R.S. 1999. Solvent-free organic syntheses using supported reagents and microwave

irradiation. Green Chem., 1(1), pp. 43-55.

Zou, Y., Lu, Y dan Wei, D. 2004. Antioxidant Activity of a Flavonoid-Rich Extract of

Hypericum perforatum L. In vitro. J. Agric. Food Chem 52: 5032-5039.




DOI: https://doi.org/10.33559/mi.v12i10.1014

Article Metrics

Sari view : 223 times
PDF - 1535 times

Refbacks

  • Saat ini tidak ada refbacks.


##submission.copyrightStatement##

INDEXED BY :

 


Lembaga Penelitian & Pengabdian Masyarakat (LPPM). Universitas Muhammadiyah Sumatera Barat
Jl. Pasir Kandang No.4, Pasie Nan Tigo, Kec. Koto Tangah, Kota Padang, Sumatera Barat 25586. 
Email : lppmumsb@gmail.com



Kunjungan Sampai Saat ini    Web Analytics Made Easy - StatCounter

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.