SINTESIS DAN UJI ANTIOKSIDAN SENYAWA (E)-1-(2-KLOROFENIL)-3-P-TOLILPROP-2-EN-1-ON
Sari
Halogen substituted analog compound chalcone(E)-1-(2-chlorophenyl)-3-ptolylprop-
2-en-1-on was synthesized from 4-metylbenzaldehyde as aldehydes with 2-
chloroacetophenone, as ketones by using aldol condensation reaction. The compound
resulted rendement with value of 60,08% and characterized by using UV, IR, MS, and
1HNMR. Test of antioxidant activity using DPPH method showed that those compounds
have low potency as antioxidant agent LC50 with value 620,4506ppm.
Keywords: Antioxidant, DPPH, Chalcone, dan Synthesis
Teks Lengkap:
PDFReferensi
Barhe, T.A dan Tchouya, G.R. 2014. Comparative Study of the Anti-oxidant Activity of the
Total Polyphenols Extracted from Hibiscus Sabdariffa L., Glycine max L Merr.,
Yellow Tea and Red Wine through Reaction with DPPH Free Radical. Arabian
Journal of Chemistry. 9:1-8.
Brahmana, E.M. 2015. Sintesis dan uji antibakteri senyawa (E)-1-(2-klorofenil)-3-ptolilprop-
-en-1-on. Jurnal Ilmiah Edu Research 4(2):103-108.
Choudhary, A.N., & Juyal, V. 2011. Synthesis of chalcone and their derivates as
antimicrobial agents. International journal of pharmacy and pharmaceutical
Sciences, 3(3): 125-128.
Jayapal, M.R., Prasad, K.S., & Sreedhar, N.Y. 2010. Synthesis and Characterization of 2,6-
Dihydroxy Substituted Chalcones Using PEG-400 as a Recyclable Solvent. Journal
of Pharmaceutical Science and Research. 2(8): 450-458.
Kakati, D., & Sarma ,J.C. 2011. Microwave Assisted Solvent Free Synthesis of 1,3-
Diphenylpropenones. Chemistry Central Journal. 5(8): 1-5.
Tiwari, B., Pratapwar, A.S., Tapas, A.R., Butle, S.R., & Vatkar, B.S. 2010. Synthesis and
Antimicrobial Activity of Some Chalcone Derivatives. International Journal of
ChemTech Research. 1(2): 499-503.
Vaismaa, M. 2009, Development of benign synthesis of some terminal a-hydroxy ketones
and aldehiydes. Disertasi: Faculty of Science University of Oulu.
Varma, R.S. 1999. Solvent-free organic syntheses using supported reagents and microwave
irradiation. Green Chem., 1(1), pp. 43-55.
Zou, Y., Lu, Y dan Wei, D. 2004. Antioxidant Activity of a Flavonoid-Rich Extract of
Hypericum perforatum L. In vitro. J. Agric. Food Chem 52: 5032-5039.
DOI: https://doi.org/10.33559/mi.v12i10.1014
Article Metrics
Sari view : 223 timesPDF - 1535 times
Refbacks
- Saat ini tidak ada refbacks.
##submission.copyrightStatement##
INDEXED BY :
Lembaga Penelitian & Pengabdian Masyarakat (LPPM). Universitas Muhammadiyah Sumatera Barat
Jl. Pasir Kandang No.4, Pasie Nan Tigo, Kec. Koto Tangah, Kota Padang, Sumatera Barat 25586.
Email : lppmumsb@gmail.com
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.