Biomarker Penyakit Periodontal Pada Saliva: Scoping Review

Maulida Hayati, Suci Indah Kurnia, Fauzia Nilam Orienty

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Penyakit periodontal merupakan salah satu penyakit rongga mulut yang banyak terjadi di masyarakat. Penyakit periodontal terbagi menjadi dua, yaitu gingivitis dan periodontitis. Biomarker penyakit periodontal terdapat pada saliva yang berfungsi untuk menentukan perkembangan, memantau dan mendiagnosis penyakit periodontal. Tujuan dari scoping review ini adalah untuk menentukan biomarker penyakit periodontal pada saliva. Metode dalam penelitian ini menggunakan metode studi kepustakaan yaitu data yang diperoleh dengan membaca, mempelajari dan memahami melalui media lain yang bersumber dari kepustakaan. Pencarian data dilakukan melalui database PubMed, Science Direct, Wiley Online Library dan Google Scholar. Hasil scoping review dari 18 artikel menyatakan bahwa terdapat biomarker saliva pada penyakit periodontal. Berdasarkan hasil review terhadap 18 artikel ditemukan biomarker penyakit periodontal pada saliva, biomarker inflamasi IL-1β dan IL-6, biomarker jaringan ikat terdegradasi MMP-8, MMP- 9, TIMP-1, Aspartat Aminotransferase dan Alkali. Fosfatase. Sedangkan prostaglandin (PGE2), Carboxy-terminal telopeptide of type I collagen (ICTP) dan TNF- merupakan biomarker untuk resorpsi tulang alveolar.

Kata Kunci: Biomarker, Penyakit Periodontal, Saliva


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Referensi


AlMoharib, H. S. et al. (2014) ‘Oral fluid based biomarkers in periodontal disease: part 1. Saliva.’, Journal of international oral health : JIOH, 6(4), pp. 95–103.

Buzalaf, M. A. R. et al. (2020) ‘Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers?’, Expert Review of Molecular Diagnostics, 20(5), pp. 543–555. doi: 10.1080/14737159.2020.1743686.

Canyon Hydro et al. (2013) ‘We are IntechOpen , the world ’ s leading publisher of Open Access books Built by scientists , for scientists TOP 1 %’, Intech, 32(July), pp. 137–144.

Dawes, C. and Wong, D. T. W. (2019) ‘Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health’, Journal of Dental Research, 98(2), pp. 133–141. doi: 10.1177/0022034518816961.

Dietrich, T. et al. (2013) ‘The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease’, Journal of Clinical Periodontology, 40(SUPPL. 14), pp. S70–S84. doi: 10.1111/jcpe.12062.

Douglas-de-, D. W. et al. (2019) ‘Periodontal disease , peri-implant disease and levels of salivary over 5 years Abstract’, J Appl Oral Sci, 27, pp. 1–7.

Dye, B. A. (2017) ‘The Global Burden of Oral Disease: Research and Public Health Significance’, Journal of Dental Research, 96(4), pp. 361–363. doi: 10.1177/0022034517693567.

Fitri, H. et al. (2019) ‘Efek Pemberian Zink Pasca Scaling Root Planning Terhadap Kadar Mmp-8 Saliva Pada Pasien Gingivitis’, B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah, 6(2), pp. 132–141. doi: 10.33854/jbd.v6i2.268.

Frencken, J. E. et al. (2017) ‘Global epidemiology of dental caries and severe periodontitis – a comprehensive review’, Journal of Clinical Periodontology, 44, pp. S94–S105. doi: 10.1111/jcpe.12677.

Giannobile, W. V. (2012) ‘Salivary diagnostics for periodontal diseases’, Journal of the American Dental Association, 143(October), pp. 6S-11S. doi: 10.14219/jada.archive.2012.0341.

Hamzah, Z. (2011) ‘Saliva as a future potential predictor for various periodontal diseases’, Dental Journal (Majalah Kedokteran Gigi), 44(2), p. 77. doi: 10.20473/j.djmkg.v44.i2.p77-81.

Heriyanto, H. (2018) ‘Thematic Analysis sebagai Metode Menganalisa Data untuk Penelitian Kualitatif’, Anuva: Jurnal Kajian Budaya, Perpustakaan, dan Informasi, 2(3), pp. 317–324. doi: 10.14710/ANUVA.2.3.317-324.

Kaczor-Urbanowicz, K. E. et al. (2017) ‘Saliva diagnostics – Current views and directions’, Experimental Biology and Medicine, 242(5), pp. 459–472. doi: 10.1177/1535370216681550.

Kemenkes RI (2018) Laporan Nasional, Kementerian Kesehatan RI.

Korte, D. L. and Kinney, J. (2016a) ‘Personalized medicine: An update of salivary biomarkers for periodontal diseases’, Periodontology 2000, 70(1), pp. 26–37. doi: 10.1111/prd.12103.

Korte, D. L. and Kinney, J. (2016b) ‘Personalized medicine: An update of salivary biomarkers for periodontal diseases’, Periodontology 2000, 70(1), pp. 26–37. doi: 10.1111/PRD.12103.

Kusuma,Nila.2015.Patologi dan Fisiologi Saliva.Padang.Andalas University Press.

Lai, J. Y. (2013) ‘Diagnosis of Periodontal Diseases’, Comprehensive Preventive Dentistry, pp. 43–60. doi: 10.1002/9781118703762.CH3.

Latifah, L. and Ritonga, I. (2020) ‘Systematic Literature Review (SLR): Kompetensi Sumber Daya Insani Bagi Perkembangan Perbankan Syariah Di Indonesia’, Al Maal: Journal of Islamic Economics and Banking, 2(1), p. 63. doi: 10.31000/almaal.v2i1.2763.

Lesmana, D., Tjahajawati, S. and Lubis, V. T. (2016) ‘Saliva Sebagai Biomarker Potensial Diagnostik ( Saliva As a Potential Diagnostic of Biomarker of’, Dentika Dental Journal, 19(2), pp. 160–167.

Lorenzo-Pouso, A. I. et al. (2018) ‘Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases’, Disease Markers, 2018. doi: 10.1155/2018/6141845.

Malathi, N., Mythili, S. and Vasanthi, H. R. (2014) ‘Salivary Diagnostics: A Brief Review’, ISRN Dentistry, 2014, pp. 1–8. doi: 10.1155/2014/158786.

Narang, R. et al. (2013) ‘Salivary biomarkers for periodontal diseases-A review’, Bangladesh Journal of Medical Science, 12(3), pp. 244–249. doi: 10.3329/bjms.v12i3.15405.

Panat, S. R. et al. (2013) ‘Sialochemistry – An Emerging Oral Diagnostic Tool’, Journal of Dental Sciences & Oral Rehabilitation, (October 2013), pp. 1–3.

Penteado, C. A. S. et al. (2020) ‘Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents’, Oral Diseases, 26(6), pp. 1200–1208. doi: 10.1111/ODI.13337.

Peters, M. et al. (2015) ‘The Joanna Briggs Institute Reviewers’ Manual 2015: Methodology for JBI Scoping Reviews’.

Prakash, A. et al. (2016) ‘Salivary alkaline phosphatase levels speak about association of smoking, diabetes and potentially malignant diseases?’, Journal of Oral and Maxillofacial Pathology, 20(1), pp. 66–70. doi: 10.4103/0973-029X.180934.

Sexton, W. M. et al. (2011) ‘Salivary biomarkers of periodontal disease in response to treatment’, Journal of Clinical Periodontology, 38(5), pp. 434–441. doi: 10.1111/j.1600-051X.2011.01706.x.

Sugiyono (2012) Memahami Penelitian Kualitatif. Bandung: ALFABETA.

Sukriti, K. C., Wang, X. Z. and Gallagher, J. E. (2020) ‘Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review’, Journal of Clinical Periodontology, 47(3), pp. 289–308. doi: 10.1111/jcpe.13218.

Tonetti, M. S. et al. (2017) ‘Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action’, Journal of Clinical Periodontology, 44(5), pp. 456–462. doi: 10.1111/jcpe.12732.

Tricco, A. et al. (2018) ‘PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation’, Annals of internal medicine, 169(7), pp. 467–473. doi: 10.7326/M18-0850.

Wahono, R. S. (2011) ‘A Systematic Literature Review of Software Defect Prediction: Research Trends, Datasets, Methods and Frameworks’, Journal of Software Engineering, 1(1), pp. 1–16. doi: 10.3923/jse.2007.1.12.

Xingqun, C., Xuedong, Z. and Xin, X. (2016) ‘Application of saliva in disease diagnosis’, Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 34(6), pp. 647–653. doi: 10.7518/hxkq.2016.06.019.

Zhang, C. Z. et al. (2016) ‘Saliva in the diagnosis of diseases’, International Journal of Oral Science, 8(3), pp. 133–137. doi: 10.1038/ijos.2016.38.




DOI: https://doi.org/10.31869/mi.v17i2.4120

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