PENINGKATAN KUALITAS HIDUP PASIEN TUBERKOLOSIS DENGAN HIPERSENSITIVITAS OAT MELALUI TERAPI INTEGRATIF: A CASE REPORT

Ni Ketut Sujati, Laila Fadhilah, Nelly Rustiati, Lisdahayati Lisdahayati, M Agung Akbar

Sari


Pendahuluan: Tuberkulosis (TB) merupakan penyakit infeksi kronis yang masih menjadi masalah kesehatan global dengan angka kejadian tinggi dan munculnya resistensi terhadap obat anti-tuberkulosis (OAT). Penggunaan OAT jangka panjang sering menimbulkan reaksi hipersensitivitas yang dapat menurunkan kepatuhan terapi dan kualitas hidup pasien. Pendekatan terapi integratif melalui kombinasi akupunktur, herbal, fisioterapi, dan modifikasi diet diharapkan dapat mengurangi efek samping OAT dan mempercepat pemulihan. Tujuan: Penelitian ini bertujuan untuk menganalisis efektivitas penerapan terapi integratif terhadap peningkatan kualitas hidup pasien tuberkulosis dengan hipersensitivitas terhadap OAT. Metode: Penelitian ini menggunakan desain laporan kasus (case report) pada satu pasien perempuan berusia 25 tahun dengan diagnosis TB paru aktif dan hipersensitivitas OAT. Intervensi dilakukan selama empat bulan melalui kombinasi akupunktur, terapi herbal (Yue Hua Wan, yin chai Hu, Chaihu Shu Gan, dan Kencur), fisioterapi dada, serta modifikasi diet berbasis “Isi Piringku”. Pemantauan dilakukan terhadap gejala klinis, berat badan, tekanan darah, dan hasil pemeriksaan GeneXpert. Hasil: Setelah empat bulan intervensi, pasien mengalami peningkatan berat badan dari 35 kg menjadi 43 kg, perbaikan nafsu makan, kualitas tidur, serta penurunan gejala gastrointestinal tanpa efek samping tambahan. Hasil GeneXpert menunjukkan MTB not detected, menandakan keberhasilan eradikasi infeksi. Kesimpulan: Terapi integratif efektif dalam mengurangi reaksi hipersensitivitas OAT, meningkatkan status fungsional, dan memperbaiki kualitas hidup pasien. Pendekatan ini menunjukkan sinergi positif antara pengobatan tradisional dan terapi medis konvensional. Saran: Penelitian lanjutan dengan desain uji klinis terkontrol diperlukan untuk menilai efektivitas jangka panjang dan mengembangkan panduan praktik terapi integratif pada pasien tuberkulosis dengan hipersensitivitas obat.


Teks Lengkap:

PDF

Referensi


Benjamin, K., Arya, N., Corinne, K., Tracy, S., Eve, W., Elidania, P., & Woodson, M. (2018). Acupuncture therapy in a group setting for chronic pain. Pain Medicine, 19(2), 393–403. https://doi.org/10.1093/pm/pnx134

Catherine, H., & Lorenzo, G. (2021). Cardiac safety of multidrug-resistant tuberculosis treatment: Moving towards individualized monitoring. The Lancet Infectious Diseases, 21(7), 894–895. https://doi.org/10.1016/S1473-3099(20)30836-7

Cheng, W., Tan, S., Li, Y., & Li, Q. (2021). Clinical characteristics of recurrent bacterial negative pulmonary tuberculosis patients. Chinese Journal of Antituberculosis, 43(10), 1006–1009. https://doi.org/10.3969/j.issn.1000-6621.2021.10.006

Chinese Society for Tuberculosis, Chinese Medical Association. (2023). Expert consensus on diagnosis and treatment of elderly pulmonary tuberculosis. Zhonghua Jie He He Hu Xi Za Zhi, 46(12), 1068–1084. https://doi.org/10.3760/cma.j.cn112147-20230921-00182

Fu, K., Xu, M., Zhou, Y., Li, X., Wang, Z., Liu, X., Meng, X., Zeng, Y., & Zhang, H. (2020). The status quo and way forwards on the development of Tibetan medicine and the pharmacological research of Tibetan materia medica. Pharmacological Research, 155, 104688. https://doi.org/10.1016/j.phrs.2020.104688

Han, L. Y., Gao, Y. H., & Yu, G. L. (2020). The therapeutic effect of carnosine combined with dexamethasone in the lung injury of seawater-drowning. Chinese Journal of Tuberculosis and Respiratory Diseases, 43(10), 772–777. https://doi.org/10.3760/cma.j.cn112147-20191028-00717

Li, G., Xu, Z., Jiang, Y., Liu, H., Zhao, L. L., Li, M., Xu, D., Zhao, X., Liu, Z., Wang, R., & Wan, K. (2019). Synergistic activities of clofazimine with moxifloxacin or capreomycin against Mycobacterium tuberculosis in China. International Journal of Antimicrobial Agents, 54(6), 642–646. https://doi.org/10.1016/j.ijantimicag.2019.06.002

Li, X., Li, X., Liu, Q., Sun, N., Zhang, B., Shi, C., & Zhang, R. (2020). Traditional Chinese medicine combined with Western medicine for the treatment of secondary pulmonary tuberculosis: A PRISMA-compliant meta-analysis. Medicine (Baltimore), 99(9), e19567. https://doi.org/10.1097/MD.0000000000019567

Liang, Y., Yang, X., Liu, M., Li, Y., & Zhang, Y. (2021). Clinical efficacy and nursing experience of treating pulmonary tuberculosis with levofloxacin associated with antituberculosis drugs. Indian Journal of Pharmaceutical Sciences, 83(3), 202–205. https://doi.org/10.36468/pharmaceutical-sciences.spl.277

Liu, A., Yin, X., Wang, R., Cheng, L., Zhang, Y., Tu, F., Ma, J., & Zhong, Y. (2023). Analysis of the effect of anti-tuberculosis therapy combined with all-in-one nursing care on the alleviation of inflammation in patients with pulmonary tuberculosis. Cellular and Molecular Biology, 69(1), 131–136. https://doi.org/10.14715/cmb/2022.69.1.23

Liu, Y., Li, Y., Liu, M., Zhang, M., Wang, J., & Li, J. (2024). Effects of acupuncture-point stimulation on perioperative sleep disorders: A systematic review with meta-analysis and trial sequential analysis. International Journal of Clinical Practice, 2024, 6763996. https://doi.org/10.1155/2024/6763996

Liu, Y., Zeng, S., Li, Y., Zhuang, G., Su, Y., Liu, X., Chen, L., & Feng, Q. (2020). The effect of acupoint application of traditional Chinese medicine for the treatment of chronic obstructive pulmonary disease: A protocol for systematic review and meta-analysis. Medicine (Baltimore), 99(6), e22730. https://doi.org/10.1097/MD.0000000000022730

Manjit, S. T., Rahul, T., & Ajay, H. (2021). Review of advances in diagnosis and treatment of pulmonary tuberculosis. Indian Journal of Tuberculosis, 68(4), 510–515. https://doi.org/10.1016/j.ijtb.2021.07.002

Min, B., Wang, X., Pu, Y., & Yan, J. (2022). Clinical efficacy of psychotherapy combined with acupoint herbal application on elderly patients with pulmonary tuberculosis: An exploratory study. International Journal of General Medicine, 15, 4029–4035. https://doi.org/10.2147/IJGM.S354002

Mingxiang, H., Yaoju, T., Xuxia, Z., Yufeng, W., Biyi, S., Zhongtan, X., Jingping, W., & Yu, P. (2022). Effect of mixed infections with Mycobacterium tuberculosis and nontuberculous mycobacteria on diagnosis of multidrug-resistant tuberculosis: A retrospective multicentre study in China. Infection and Drug Resistance, 15, 157–166. https://doi.org/10.2147/IDR.S341817

Nandika, M. P., Kanya, W. D., Azriel, S., Ayu, S. P., & Krisna, M. A. (2022). Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment: A systematic review of cohort studies. Oman Medical Journal, 37(4), 337–342. https://doi.org/10.5001/omj.2021.64

Qiao, C. F., Han, Q. B., Song, J. Z., Mo, S. F., Kong, L. D., Kung, H. F., & Xu, H. X. (2007). Chemical fingerprint and quantitative analysis of Fructus Psoraleae by high-performance liquid chromatography. Journal of Separation Science, 30(6), 813–818. https://doi.org/10.1002/jssc.200600339

Shetty, N., Shemko, M., Vaz, M., & D’Souza, G. (2006). An epidemiological evaluation of risk factors for tuberculosis in South India: A matched case-control study. International Journal of Tuberculosis and Lung Disease, 10(1), 80–86.*

Shou, Y., Hu, L., Zhang, C., Xu, S., Jin, Q., Huang, L., Li, B., Yuan, L., Xu, S., Zhang, K., & Zhang, B. (2020). Efficacy of acupuncture at three nasal acupoints plus acupoint application for perennial allergic rhinitis: A multicenter, randomized controlled trial protocol. Trials, 21(1), 110. https://doi.org/10.1186/s13063-019-4039-3

Stpień, A., Brudo, M., & Stachura, T. (2020). Miliary pulmonary tuberculosis after the first dose of intravesical BCG instillation in a patient with high-grade bladder cancer. Advances in Respiratory Medicine, 88(6), 628–629. https://doi.org/10.5578/mb.20239955

Verma, N., Arora, V., Awasthi, R., Chan, Y., Jha, N. K., Thapa, K., Jawaid, T., Kamal, M., Gupta, G., Liu, G., Paudel, K. R., Hansbro, P. M., Oliver, B. G. G., Singh, S. K., Chellappan, D. K., Dureja, H., & Dua, K. (2022). Recent developments, challenges and future prospects in advanced drug delivery systems in the management of tuberculosis. Journal of Drug Delivery Science and Technology, 75, 103690. https://doi.org/10.1016/j.jddst.2022.103690

Wáng, Y. X. J., Chung, M. J., Skrahin, A., Rosenthal, A., Gabrielian, A., & Tartakovsky, M. (2018). Radiological signs associated with pulmonary multi-drug resistant tuberculosis: An analysis of published evidence. Quantitative Imaging in Medicine and Surgery, 8(2), 161–173. https://doi.org/10.21037/qims.2018.03.06

Wei, C., Zhang, X., Li, P., & Li, W. (2020). Acupoint herbal patching during Sanfu Days on reducing frequency of acute asthma attack in children: A systematic review and meta-analysis. Medicine (Baltimore), 99(32), e18962. https://doi.org/10.1097/MD.0000000000018962

Xiaochao, G., Zhenyu, L., Liang, L., Suge, L., & Dantong, Z. (2021). Research progress of acupoint application therapy. Family Life Guide, 37(2), 63–64.*

Xiao, Z., Chen, Z., Han, R., Lu, L., Li, Z., Lin, J., Hu, L., Huang, X., & Lin, L. (2021). Comprehensive TCM treatments combined with chemotherapy for advanced non-small cell lung cancer: A randomized, controlled trial. Medicine (Baltimore), 100(3), e25690. https://doi.org/10.1097/MD.0000000000025690

Xian, Z. S., Lei, Q., Cui, L., Wei, Z., Ming, T. L., Yong, Z. H., Feng, M. Z., Wei, W. X., Xing, H., Wei, J. Y., Yan, Z. S., & Hui, L. Z. (2021). Efficacy of integrating short-course chemotherapy with Chinese herbs to treat multi-drug resistant pulmonary tuberculosis in China: A study protocol. Infectious Diseases of Poverty, 10(1), 131. https://doi.org/10.1186/s40249-021-00913-5

Zhang, S. Y., Fu, J. Y., Guo, X. Y., Wu, D. Z., Zhang, T., Li, C., Qiu, L., Shao, C. R., Xiao, H. P., Chu, N. H., Deng, Q. Y., Zhang, X., Yan, X. F., Wang, Z. L., Zhang, Z. J., Jiang, X., Zheng, Y. J., Zheng, P. Y., Zhang, H. Y., & Lu, Z. H. (2020). Improvement cues of lesion absorption using adjuvant therapy of traditional Chinese medicine Qinbudan tablet for retreatment pulmonary tuberculosis with standard anti-tuberculosis regimen. Infectious Diseases of Poverty, 9(50). https://doi.org/10.1186/s40249-020-00660-z

Zignol, M., Hosseini, M. S., Wright, A., Weezenbeek, C. L., Nunn, P., Watt, C. J., Williams, B. G., & Dye, C. (2006). Global incidence of multidrug-resistant tuberculosis. Journal of Infectious Diseases, 194(4), 479–485. https://doi.org/10.1086/505877

Zheng, L. H., Yu, J. L., Sun, P., Li, H. Q., Chen, D., Yu, Y. J., Ni, S., Xu, M., Cheng, Y., Ma, C. G., Zhao, C. Y., Yang, N., Li, G. J., & Li, J. (2018). Clinical efficacy analysis of Qingfei Qulao Pill in the treatment of patients with relapsed pulmonary tuberculosis. Journal of Tuberculosis and Lung Health, 7(2), 114–119. https://doi.org/10.3969/j.issn.2095-3755.2018.02.008




DOI: https://doi.org/10.31869/mm.v8i2.7374

Article Metrics

Sari view : 0 times
PDF - 0 times

Refbacks

  • Saat ini tidak ada refbacks.


 Kunjungan Saat ini

Kunjungan Dari Negara

 Flag Counter

 

 

Creative Commons License
Menara Medika is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.